Therapeutic Plasma Exchange (TPE)

Your blood carries more than oxygen and nutrients. But It also carries inflammatory waste, aging signals, and cellular damage that quietly accelerate the aging process.

What if you could filter that out—and give your body a cleaner, younger internal environment to thrive in?

That’s the promise of Therapeutic Plasma Exchange (TPE)—a longevity protocol that’s now gaining real traction.

Quick Take:
🔴 Cost: $2,000–$5,000 per session (not widely accessible)
🟠 Actionable: Limited access, but mimicking the benefits is can be achievable
🟢 Impact: High potential for reducing biological age and systemic inflammation

The Idea

TPE works by:

1. Removing the liquid part of your blood (plasma)

2. Leaving your red and white blood cells intact

3. Replacing the plasma with sterile albumin, a protein naturally found in young plasma

This isn’t young blood transfusion or PRP (therapies we’ll explore in time)
It’s a simple swap: old, pro-aging plasma out. Fresh, clean plasma in.

Your body gets a cleaner internal environment. Your cells get better fuel.

The Evidence

It’s early—but the direction is compelling.

This is one of the few interventions that doesn’t rely on pills, genes, or drugs—just better biochemistry.

Research, and Human TPE trials are showing:

• ⚖️ Reduced inflammation markers (like CRP and IL-6)

• 🧠 Improved cognition and subjective vitality

• 🧬 Favorable shifts in biological age markers

📚 Studies worth exploring:

- Old plasma dilution reduces human biological age: a clinical study via Springer (2002).
- Young Plasma Rejuvenates Blood DNA Methylation Profile, Extends Mean Lifespan, and Improves Physical Appearance Institute for Biochemical Research Argentina (2024)

🎧 The Science Of Aging: Diving Into Therapeutic Plasma Exchange With Dr. Irina Conboy. Finding Genius Podcast.

🖥️ “I Swapped My Plasma”: Bryan Johnson’s longevity protocol to become the world’s longest living person. Bryan Johnson YouTube.

The Action

TPE is currently:

• FDA-approved for autoimmune conditions

• Used off-label in high-end longevity clinics

• Embraced by biohackers like Bryan Johnson, who includes it in his plasma stacking routine

But it’s not cheap. A single session can cost $2,000–$5,000, and it’s not yet mainstream.

Here’s 5 Ways to Mimic Plasma Exchange Benefits (Without the $5K Price Tag):

1. Lower Inflammation Through Diet
   Eat more fiber, polyphenols, and omega-3s. Focus on leafy greens, berries, cruciferous veggies, flaxseeds, and fatty fish.
   

2. Hydrate Like It’s Therapy
   Your kidneys and liver are natural detox machines—but only if they’re well-hydrated. Aim for 2.5–3L of water daily, and add electrolytes if you’re active or fasting.
   

3. Use Fasting to Clear Cellular Waste
   Try 12–16 hour daily fasting or go deeper with a quarterly 72-hour water fast or a 5-day Fasting Mimicking Diet (FMD). These promote autophagy, lower inflammation, and shift your plasma profile toward repair.
   

4. Break a Sweat, Often
   Exercise boosts circulation and lymph flow, helping your body clear out damaged proteins. Combine resistance training, cardio, and sauna use (3–5x/week) to mimic detox and plasma turnover.
   

5. Manage Mental Inflammation Too
   Chronic stress elevates inflammation. Use breathwork, meditation, or NSDR (Non-Sleep Deep Rest) for 10–20 minutes per day to keep cortisol in check.

Aging is partly a story of buildup—and your job is to keep clearing the junk.

What’s Next?

Therapeutic Plasma Exchange (TPE) is one of the most promising interventions in the longevity world today. But like many advanced therapies, it’s not the only path forward—and in many cases, you can replicate much of its benefit through simple, consistent lifestyle upgrades.

Quality sleep, nutrient-dense food, consistent movement, and stress you can actually manage— optimize these, and you’re already winning the healthspan game.

To simple, smart lifestyle choices every single day.

Longevity Daily

P.S. Do you like learning about these cutting-edge therapies? Reply to this email, I’d love to know.